The gene DDX41 encodes the nuclear enzyme, DEAD-box-type RNA helicase. Mutation of DDX41 leads to hematopoietic cancers. However, the mechanism underlying this malignancy development is unclear. To ...

New research has revealed how a common inherited mutation in the DDX41 gene – one of the most common genetic risk factors for bone marrow cancers – can disrupt red blood cell development and activate ...

A new editorial paper was published in Oncotarget's Volume 15 on July 2, 2024, entitled, "DDX41 and its unique contribution to myeloid leukemogenesis." In this new editorial, researcher Hirotaka ...

Biallelic DDX41 mutations cause cell death of blood progenitor cells, leading to bone marrow failure and atrophy of the spleen in genetic mouse models. Disclaimer: AAAS and EurekAlert! are not ...

From birth, our immune system is ready to spring into action to protect us from pathogenic invaders. Like the rest of the immune system, the innate immune system has to be carefully controlled, and ...

Cancer research experts report on discovering a rare population of cells that help create a polluted bone marrow environment that in turn allows other mutated cells to trigger MDS. In the United ...

The case study, which showed prolonged disease control achieved with gilteritinib in a previously-treated patient with AML with an inv(2)(p23q13) translocation, indicates that gilteritinib can also be ...