PERPHENAZINE and other phenothiazines are widely used for their potent antiemetic and tranquilizing properties. Various toxic reactions to these agents have been reported. To enhance the therapeutic ...

The approval of Osmolex ER was based on bioavailability studies comparing Osmolex ER to immediate-release amantadine. Osmotica announced that the Food and Drug Administration (FDA) has approved ...

Amantadine HCl 129mg, 193mg; ext-rel tabs. The mechanism by which amantadine exerts efficacy in the treatment of Parkinson’s disease and drug-induced extrapyramidal reactions is unknown. Amantadine is ...

AS the so-called "tranquilizing drugs" continue to increase in use and misuse, the physician will become more aware of the alarming side reactions that may be inherent in their pharmacologic formulas.

EPSs are serious, debilitating and stigmatizing adverse effects that frequently require additional pharmacotherapy. 3 The two types of EPSs are as follows: early acute EPS, which most often develops ...

Ondansetron is a selective 5-HT3 antagonist with significant antiemetic properties in patients receiving cytotoxic chemotherapy. Patients who had suffered severe vomiting on carboplatin alone (23 ...