ProImmune, a leader in services for understanding and managing adaptive immune responses, announced the introduction of ProT2, a range of human MHC class II tetramer reagents for tetramer analyses in ...

Lung immunity is essential to combat all pulmonary diseases, including COVID-19, pneumonia, lung cancer, asthma, and COPD. Lung immunity differs from the systemic immunity which is the normal focus of ...

Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion, tumor heterogeneity, and immune-related adverse events.

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity. This review synthesizes emerging mechanistic evidence showing that ...

The repertoire of αβ T cell antigen receptors (TCRs) on mature T cells is selected in the thymus where it is rendered both self-tolerant and restricted to the recognition of major histocompatibility ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2005 ASCO Annual Meeting. This abstract does not include a full text component.

In the ever-evolving world of cell therapy, researchers often turn to T cells—a type of white blood cell—to transform the way we treat cancer. This is true for CAR T therapy, a modern cancer ...

In autoimmune diseases, CD4+ T cells targeted to self- antigens multiply and attack the body's own tissues. The resulting inflammation and cell damage leads to disease such as diabetes, rheumatoid ...

Researchers have found that control of immunity in the lungs is accomplished by cells that line the air spaces, epithelial cells, using a specialized immune-facing molecule, MHC-II. This epithelial ...

Major Histocompatibility Complex (MHC) molecules display antigens to T cells, immune cells that constantly check for infected or damaged cells. If T cells spot MHC molecules with foreign antigens or ...