The authors show that polymerase ε's processivity is abrogated by mutation to alanine of three residues in the P domain (His748, Arg749, Lys751) that lie near the phosphate backbone approximately 10 ...
Recent crystallographic studies of φ29 DNA polymerase have provided structural insights into its strand displacement and processivity. A specific insertion named terminal protein region 2 (TPR2), ...
Applications that need accurate replication often require large amounts of high-quality DNA for analysis and archiving. Areas where high fidelity, low mutation whole genome amplification (WGA) is ...