49ers 48-27 Colts (Dec 22, 2025) Box Score - ESPN
5 hours ago · Box score for the San Francisco 49ers vs. Indianapolis Colts NFL game from December 22, 2025 on ESPN. Includes all passing, rushing and receiving stats.
49ers vs. Colts live updates: Brock Purdy explodes for five TDs – …
7 hours ago · Here’s everything you need to know from the San Francisco 49ers' 48-27 win over the Indianapolis Colts on Monday at Lucas Oil Stadium.
49ers vs. Colts: Brock Purdy lights up Indy for 5 TDs, spoils Philip ...
Dec 24, 2025 · 49ers vs. Colts: Brock Purdy lights up Indy for 5 TDs, spoils Philip Rivers' season debut at home in 48-27 win Bills, Jaguars and Chargers clinch playoff spots on Colts' defeat …
Colts vs. 49ers score, highlights, stats, takeaways from MNF
9 hours ago · Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.
49ers vs Colts final score, results: Brock Purdy throws five …
8 hours ago · The San Francisco 49ers have officially put their playoff destiny in their own hands. With a 48-27 win over the Indianapolis Colts on "Monday Night Football," San Francisco will …
Purdy throws career high 5 TD passes, leads 49ers past Colts 48 …
2 hours ago · Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory at …
49ers vs. Colts highlights: SF extends win streak to 5 games - MSN
6 hours ago · The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.
49ers vs. Colts live updates: NFL ‘Monday Night Football’ score ...
10 hours ago · The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy’s career-high five touchdown passes. Christian McCaffrey …
Indianapolis Colts vs San Francisco 49ers results, score, Philip Rivers
8 hours ago · The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, highlights
49ers vs. Colts MNF Highlights: Purdy's Career Night, Rivers Pick …
6 hours ago · A meeting featuring two of the NFL's best in Christian McCaffrey and Jonathan Taylor will close Week 16 as the 49ers and Colts clash in a matchup with playoff implications.