Uridine 5'-diphospho-glucuronosyltransferase (UDP -glucuronosyltransferase, UDPGT or UGT) is a microsomal glycosyltransferase (EC 2.4.1.17) that catalyzes the transfer of the glucuronic acid …

UGT is the master enzyme governing detoxification, drug response, and hormone balance. Discover how its function shapes your unique health profile.

This review discusses recent advances in the understanding of the functional roles of UGT, their regulation and tissue expression, and clinical significant factors (ontogeny, interactions and …

Dec 27, 2021 · The UGT family of enzymes is responsible for an important part of phase II detoxification. In this article, I’ll explain what the UGT enzymes do in the body, how your genes impact this part of …

All UGT genes that have been named by the committee and associated publicly available information are available for download. The latest publicly available UGT names and sequences (up until 11 …

Jul 1, 2017 · Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the most important phase II mechanisms, responsible for around 35% of phase II metabolisms.

Results are interpreted for the purposes of UGT1A1 drug metabolism and hereditary hyperbilirubinemia syndromes (Gilbert syndrome and Crigler-Najjar syndrome). This test does not include …

UDP-glucuronosyltransferase (UGT) is an enzyme that plays a critical role in the biotransformation and metabolism of various substances by catalyzing the process of glucuronidation.

Nov 20, 2023 · In this study, we comprehensively analyzed the transcriptome of 22 UGTs in 54 human tissues/regions using RNAseq data from GTEx. We then validated the findings in the liver and small …

Jan 1, 2024 · UGTs are characterized primarily by their ability to glucuronidate a wide range of structurally unrelated compounds. They have a significant impact on both the metabolism of …