🌺Theta cell or Knizocyte found in Southeast Asian Ovalocytosis (SAO)🌺 🌺 Southeast Asian Ovalocytosis (SAO) and Malaria Resistance🌺 🌺SAO is a hereditary red blood cell membrane disorder caused by a mutation in the SLC4A1 gene (band 3 protein), resulting in rigid RBCs with a Theta cell appearance (RBCs with two stomas). 🍁Mechanisms of resistance to Plasmodium falciparum: 🔸Rigid RBCs → Parasites have difficulty entering and developing 🔸Altered Band 3 protein → Parasite adhesion is reduced,
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